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- Maleimide conjugation
The carbohydrate moiety on an antibody is located at the hinge region of the Fc domain, with a sufficient distant from the variable region that regulates antigen interaction. Therefore, conjugation involving carbohydrate moiety is unlikely to impair. www.creative-biolabs.com/adc/carbohydrate-based-conjugation.htm - Gene synthesis service
With years of experience in the gene synthesis and cloning field, Creative Biogene can provide the most professional service with fastest turnaround time to customers worldwide. www.creative-biogene.com/Services/Gene-Service/Gene-Synthesis-and-cloning-service.html - Isotope Labeled Peptides
With more than 10 years of experience, and as a world-leading peptide manufacturing organization, Creative Peptides can provide customized peptides labeled with stable isotopes including 2H, 15N & 13C, respectively, or a combination of 15N & 13C. www.creative-peptides.com/services/stable-isotope-labeled-peptides.html - Acetyl Tetrapeptide-5
Acetyl tetrapeptisde-5 is a known humectant or hydroscopic moisturizer which helps reduce eye puffiness, improve skin elasticity and overall smoothness. www.creative-peptides.com/product/acetyl-tetrapeptide-item-cpc1610-134.html - FRET-Substrates
Creative Peptides provides a wide range of fret substrates. www.creative-peptides.com/product/fret-substrates-35.html - Adc custom products
Creative Biolabs offers a variety of customarily prepared antibody-drug conjugate (ADC) products to serve the course of ADC development and evaluation. Taken advantage of our large inventory of therapeutic antibodies, our scientists help create the c www.creative-biolabs.com/adc/target-list-customized-adcs-1.htm - Cleavable linker
Linker design for ADCs is highly dependent on the biolology of the target cells, the characteristics of the antibody, and the structure of the drug molecule. Selection of the optimal linker is achieved through efficacy and toxicity assessments for ea www.creative-biolabs.com/adc/linker-module.htm - Duocarmycin adc
Duocarmycins are a series of natural products originally isolated from Streptomyces bacteria in 1988. They exhibit an impressively high cytotoxicity and are subsequently developed into anti-tumor agents. Duocarmycin analogues, among which CC-1065. www.creative-biolabs.com/adc/duocarmycins.htm - Adc payload
Antibody-drug conjugates (ADCs) are next-generation targeted anti-tumor agents that are constructed by the covalent coupling of a monoclonal antibody with a cytotoxic payload drug via a small molecular linker. As a key factor in an ADC, the payload d www.creative-biolabs.com/adc/drug-module.htm - Cysteine maleimide
Cysteine residues serve essential roles in protein structure and function due to their highly reactive thiol side chains that form inter or intra molecular di-sulfide bonds to enable correct protein folding. Thiol reactivity also provides an appealin www.creative-biolabs.com/adc/cysteine-based-conjugation.htm - Smcc
Linkers facilities the conjugation of ADC toxins to antibodies and in the meantime, they also dictate the release mechanism of an ADC. Proper linker selection will not only ease the process of obtaining the conjugate but also help enhance the chemica www.creative-biolabs.com/adc/classify-adc-linkers-7.htm - Fibroblast Cells
Fibroblasts, the most common mammalian connective tissue cells, are specialized for the secretion of collagenous extracellular matrix and are jointly responsible for the architectural framework of the body. A fibroblast cell plays a critical role in www.creative-bioarray.com/filter/fibroblast-cell-and-media-12.html - Short tandem repeat str profile
Creative Bioarray STR profiling is critical for verifying the identity of human cell lines, ensuring uniqueness of the cell line and detecting laboratory errors such as misidentification and cross-contamination of lines. www.creative-bioarray.com/Services/Short-Tandem-Repeat-Analysis.htm - Scfv screening
Creative Biolabs offers customers superior approaches for scFv generation such as the one-stop solution for developing CAR from Hybridoma or Phage Display, which manifest as mature and delicate technologies for scFv construction. www.creative-biolabs.com/car-t/scfv-generation.htm - Mouse lung fibroblasts
Mouse Primary Lung Fibroblasts are isolated from tissue of pathogen-free laboratory mice. Mouse Primary Lung Fibroblasts are grown in T25 tissue culture flasks pre-coated with gelatin-based solution for 0.5 hour and incubated in Creative Bioarray Cul www.creative-bioarray.com/mouse-lung-fibroblasts-CSC-C1937-item-39372.htm - Rat primary cells
Rat Pancreatic Islets from Creative Bioarray are isolated from the pancreas of Sprague–Dawley rat using Collagenase P and purified using Ficoll density gradient. www.creative-bioarray.com/Products/Rat-Primary-Cells-list-175.htm - Adc analysis
Empowered by our advanced high-resolution analytical platforms and experienced technical personnel, the analytical division at Creative Biolabs is fully competent and dedicated to serve as your one-stop-shop for ADC in vitro analysis and characteriza www.creative-biolabs.com/adc/adc-in-vitro-analysis.htm - Adc website
Future cancer and other infectious disease treatments requires a new type of cargo that precisely delivers the medicine to its specific target without causing undesired side-effects on healthy cells and tissue. www.creative-biolabs.com/adc/ - Linker peptide
Peptide linkers belong to protease-sensitivity linkers (also called enzymatically cleavable linkers) that have gained significant attention in ADC development due to their superior plasma stability and controled payload release mechanism. www.creative-biolabs.com/adc/peptide-linker.htm - Dhfr methotrexate
Methotrexate, a folate analogue, was initially synthesized in the 1940s to serve as a dihydrofolate reductase (DHFR) inhibitor. www.creative-biolabs.com/adc/methotrexate-dhfr-inhibitor.htm